akirlu: (Default)
Hal and I watched another episode of James Burke's BBC series Connections last night. Wow this is fascinating stuff! I never watched the series when it aired in the late 1970s, but it holds up surprisingly well for television that's three decades old. Burke is a science historian, and each episode traces the scientific and technological breakthroughs that were stepping stones to some modern technological necessity. The path through the intervening history is always complex and circuitous and each individual stop is a story in itself. The show skips lightly from exotic location to historical re-enactment, guided along by Burke's puckish narration, and inevitably draws connections that I had no previous idea of. For instance (and this will sound mega-dorky) I had simply no idea how interesting and varied is the history of coal tar. The damn' stuff turns out to be crucial to everything from artificial dyes (mauve!) to oxy-acetylene welding to the illumination of London to the invention of artificial fertilizers. And there I thought it was just good for dandruff shampoos... For anyone who means to write alternate history or alternate technology fiction, this series seems like an absolutely invaluable grounding. For that matter, for anyone doing home schooling, they could do a lot worse than getting this series for their charges. If, like me, you've somehow managed to miss it up 'til now, by all means go forth and seek it.
akirlu: (Default)
Holy shit. An article in New Scientist: Cheap, Safe Drug Kills Most Cancers says that there is an existing drug that kills cancer cells, and only cancer cells, in cultures of human cancers, and radically shrinks cancers in lab rats. Apparently, cancer cells are unique in that they don't use their mitochondria, which contain the self-destruct message for the cell, so the cancer cells never die. Dichloroacetate (DCA) works by switching the cancer cell mitochondria back on and thus causing them to shut down and die. And it's apparently been in use for years for certain rare conditions, so it's known to be fairly safe.

The problem? There's no patent on the drug. So no drug company is going to pay for clinical trials. (There's the benevolence of the invisible hand again.) Current efforts to get clinical trials going are focused on charitable and university funding.

Link thanks to [livejournal.com profile] matociquala

March 2022

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